To encourage ketone production, the amount of insulin in your bloodstream must be low. The lower your insulin, the higher your ketone production. And when you have a well-controlled, sufficiently large amount of ketones in your blood, it’s basically proof that your insulin is very low – and therefore, that you’re enjoying the maximum effect of your low-carbohydrate diet. That’s what’s called optimal ketosis.
During the 3 days of the diet, balanced nutrition is lacking. Some of the foods that are recommended are high in salt and fat and would not be appropriate for people with certain medical problems like heart disease, high blood pressure, diabetes, or high cholesterol. You may not be getting enough vitamins, minerals, and fiber while you are on the diet. If you are taking medicine for your diabetes and want to try the 3-day diet, it's important to talk with your doctor first about how to adjust your medicine.
It could be beneficial for your health and your weight loss goals to drink more water and less alcohol. Dr. Bazilian says that alcohol doesn’t have to necessarily be avoided altogether. but you should think if and where alcohol fits in the context of your overall health goals. “Aside from calories, alcohol doesn’t offer much by way of nutrition, so it’s at minimum an important decision to have going into any weight-loss program for yourself whether, how often, what type and how much may or may not fit in your timeline and goals,” she says. Alcohol also reduces inhibitions sometimes making it more challenging to make healthy eating choices, according to Dr. Bazilian. And alcohol may negatively impact sleep which plays a role in healthy metabolism, she adds. 
While 1,200 may be the right number for some, it can be super restrictive for others, says Jaclyn London, MS, RD, CDN, Nutrition Director at the Good Housekeeping Institute. Try basing your meals and snacks off this plan and double up on veggies at any opportunity — more fruit at snack time works too! You can also add an extra ounce or two of protein at all meals if you find yourself feeling hungry. The combo of fiber from produce and lean protein makes this an adaptable strategy that’ll help you lose weight safely — one meal (and snack) at a time!
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